Demalonyl derivatives of azalomycin F4 and scopafungin.
نویسندگان
چکیده
منابع مشابه
Isolation of three main components. F3, F4 and F5, from azalomycin F-complex.
Isolation of azalomycins F3, F4 and Fg from azalomycin F-complex crystals was successfully conducted. F3 was less soluble in methanol than other components and was isolated by fractional crystallization of F-complex from 80~ 100% methanol in water. F4 and F5 were separated by P-cellulose column chromatography, from which F5 and F4 were eluted with 60 % aqueous methanol and 0.01M ammonium acetat...
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Desertomycin was isolated from Streptomyces macronensis Dietz sp. nov. UC 8271. Extensive spectroscopic work led us to place desertomycin in the macrocyclic lactone family which contains monazomycin, scopafungin, primycin, azalomycin F4a and niphithricins A and B. The apparent molecular formula was determined by fast atom bombardment mass spectroscopy to be C57H109NO24 (MW = 1,191). Mild acid h...
متن کاملEffect of azalomycin F on bacteria.
It has previously been reported that azalomycin F could induce permeability changes in Candida albicans causing loss of cell constituents and inhibition of substrate uptake which resulted in the death of the organism1). The present report is concerned with the effect of the antibiotic on bacteria. Methods and Results Azalomycin F inhibited the growth of Bacillus subtilis PCI 219 at concentratio...
متن کاملScopafungin, a crystalline antibiotic produced by Streptomyces hygroscopicus var. enhygrus var. nova.
Scopafungin (U-29,479) is a crystalline, nonpolyenic antimicrobial agent obtained from the culture broth of Streptomyces hygroscopicus var. enhygrus var. nova UC-2397. Scopafungin inhibits, in vitro, a variety of pathogenic fungi, yeasts, and gram-positive bacteria.
متن کاملMechanism of Azalomycin F5a against Methicillin-Resistant Staphylococcus aureus
To investigate the mechanism of azalomycin F5a against methicillin-resistant Staphylococcus aureus (MRSA), the conductivity of MRSA suspension and the adenylate kinase activity of MRSA culture were determined with the intervention of azalomycin F5a, which were significantly increased compared to those of blank controls. This inferred that azalomycin F5a could lead to the leakage of cellular sub...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 39 5 شماره
صفحات -
تاریخ انتشار 1986